ENCODE claims that at least 80% of our genome is "biochemically functional." Larry Moran claims that there is an important distinction between "biochemical function" and "biologically relevant function," and that when one recognizes the difference between the two they will realize that most of our genome is still just "junk."
As a layman, I have no opinion on this matter. I just wanted to use the word "kerfluffel."
UPDATE: I regret to inform everybody that apparently the correct spelling is "kerfuffle." I still prefer "kerfluffel" but I bow to the dictionary gods.